Article

Identification and characterization of pleiotropic high-persistence mutations in the beta subunit of the bacterial RNA polymerase

2020-08-21

Abstract excerpt

Individual bacteria can escape killing by bactericidal antibiotics by becoming dormant. Such cells, also known as persisters, naturally occur in bacterial populations at a low frequency. Here we present the finding that antibiotic-resistance mutations in the rpoB gene, encoding the beta subunit of RNA polymerase, increase the frequency of persisters by orders of magnitude. Furthermore, we show that: i) the persis...

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Literature Corpus work: 32519664-db33-5aeb-8af7-f586c3c4285c
DOI: 10.1101/2020.08.19.258475

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