Article

Ser14-phosphorylated Rpn6 Limits Proteostasis Impairment and Pathology in Both Brain and Heart of Tauopathy Mice

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) patients often display neurobehavioral and cardiac impairments, but the underlying factors remain unclear. Ser14 phosphorylation in RPN6 (p-S14-RPN6) mediates the activation of 26S proteasomes by protein kinase A (PKA). Proteasome priming is implicated in protection by cAMP-PKA against AD, but this remains to be established. Hence, this study was conducted to interrogate...

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Literature Corpus work: 293f6d7e-2d51-5bca-92a2-f9ae711b249e
DOI: 10.1101/2025.03.24.645024

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