Article
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
Science advances - 1 May 2019
Zhang Hanming, Pan Bo, Wu Penglong, Parajuli Nirmal, Rekhter Mark D, Goldberg Alfred L, Wang Xuejun
Abstract excerpt
No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective degradation of misfolded proteins by the ubiquitin-proteasome system (UPS) is vital to the cell. Proteasome impairment contributes to HF. Activation of cAMP-dependent protein kinase (PKA) or cGMP-dependent protein kinase (PKG) facilitates proteasome functioning....
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