Article

Homeostatic Activation of 26S Proteasomes by Protein Kinase A Protects against Cardiac and Neurobehavior Malfunction in Alzheimer’s Disease Mice

2025-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s Disease (AD) patients often show brain and cardiac malfunction. AD represents a leading cause of morbidity and mortality worldwide, but the demand for effective treatment for AD is far from being met. This is primarily because AD pathogenesis, including brain-heart interaction, is poorly understood. Proteasome functional insufficiency is implicated in AD; as such, proteasome enhancem...

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Literature Corpus work: 85b1caaa-b052-5259-a5c3-b1defaaeeb9b
DOI: 10.1101/2025.03.28.645869

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