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Article

COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity.

Circulation research - 6 Nov 2015

Su Huabo, Li Jie, Zhang Hanming, Ma Wenxia, Wei Ning, Liu Jinbao, Wang Xuejun

Abstract excerpt

RATIONALE: Impaired degradation of misfolded proteins is associated with a large subset of heart diseases. Misfolded proteins are degraded primarily by the ubiquitin-proteasome system, but the ubiquitin ligases responsible for the degradation remain largely unidentified. The cullin deneddylation activity of the COP9 signalosome (CSN) requires all 8 CSN subunits (CSN1 through CSN8) and regulates cullin-RING...

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Identifiers

PMID: 26383969
DOI: 10.1161/CIRCRESAHA.115.306783
PMCID: PMC4636927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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