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Article

Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies

18 Aug 2014

Abstract excerpt

SIGNIFICANCE: Novel therapeutic strategies to treat heart failure are greatly needed. The ubiquitin-proteasome system (UPS) affects the structure and function of cardiac cells through targeted degradation of signaling and structural proteins. This review discusses both beneficial and detrimental consequences of modulating the UPS in the heart. RECENT ADVANCES: Proteasome inhibitors were first used to test the...

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Share to Cardiac Fibrosis and Remodeling
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Identifiers

PMID: 25133688
DOI: 10.1089/ars.2013.5823

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