Article

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

2021-03-18

Abstract excerpt

Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing clas...

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Literature Corpus work: 0e1aa55d-eddf-5352-83d3-01858da3cece
DOI: 10.1101/2021.03.17.435863

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