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Article

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies.

Nature communications - 7 Jul 2021

Greaney Allison J, Starr Tyler N, Barnes Christopher O, Weisblum Yiska, Schmidt Fabian, Caskey Marina, Gaebler Christian, Cho Alice, Agudelo Marianna, Finkin Shlomo, Wang Zijun, Poston Daniel, Muecksch Frauke, Hatziioannou Theodora, Bieniasz Paul D, Robbiani Davide F, Nussenzweig Michel C, Bjorkman Pamela J, Bloom Jesse D

Abstract excerpt

Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions of these different antibody classes to the polyclonal response remains unclear. Here we use a yeast-display system to map all mutations to the viral spike receptor-binding domain (RBD) that escape binding by representatives of three potently neutralizing...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34234131
DOI: 10.1038/s41467-021-24435-8
PMCID: PMC8263750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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