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Article

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies.

Cell host & microbe - 10 Mar 2021

Greaney Allison J, Loes Andrea N, Crawford Katharine H D, Starr Tyler N, Malone Keara D, Chu Helen Y, Bloom Jesse D

Abstract excerpt

The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent plasma antibodies are impacted by all mutations to the spike's receptor-binding domain (RBD), the main target of plasma neutralizing activity. Binding by polyclonal plasma antibodies is affected by mutations in three main epitopes...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33592168
DOI: 10.1016/j.chom.2021.02.003
PMCID: PMC7869748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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