Article

Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1

2023-02-03

Abstract excerpt

<h4>Background: </h4> Sepsis is associated with significant mortality, yet there are no efficacious therapies beyond antibiotics and supportive care. In adult sepsis studies, PCSK9 loss-of-function (LOF) and inhibition has shown therapeutic promise, likely through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance. In contrast, we previously demonstrated higher mortality in septic juveni...

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Literature Corpus work: 0deafb7d-7355-54cc-b985-4931c0be5244
DOI: 10.21203/rs.3.rs-2521836/v1

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