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Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock.

Critical care medicine - 1 Oct 2020

Atreya Mihir R, Whitacre Brynne E, Cvijanovich Natalie Z, Bigham Michael T, Thomas Neal J, Schwarz Adam J, Weiss Scott L, Fitzgerald Julie C, Allen Geoffrey L, Lutfi Riad, Nowak Jeffrey E, Quasney Michael W, Shah Amy S, Wong Hector R

Abstract excerpt

OBJECTIVES: Proprotein convertase subtilisin/kexin type 9 is a central regulator of lipid metabolism and has been implicated in regulating the host response to sepsis. Proprotein convertase subtilisin/kexin type 9 loss-of-function is associated with improved sepsis outcomes in the adult host through increased hepatic bacterial clearance. Thus, there is interest in leveraging proprotein convertase subtilisin/kexin...

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Identifiers

PMID: 32769621
DOI: 10.1097/CCM.0000000000004487
PMCID: PMC8477606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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