Article
Plasma Linoleic Acid Is Associated With Pediatric Sepsis Phenotype and Acute Kidney Injury.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies - 1 Apr 2026
Saraiva Ivan E, Fuhrman Dana Y, Kernan Kate F, Park Hyun-Jung, Chen Xinlei, Berg Robert A, Meert Kathleen L, Pollack Murray, Hall Mark, Newth Christopher, Harrison Rick, Shanley Thomas, Carcillo Joseph A, Gómez Hernando
Abstract excerpt
OBJECTIVES: Linoleic acid (LA) is the most abundant polyunsaturated fatty acid in diet, and it is a precursor to inflammatory lipid mediators called oxylipins. The role of LA and its oxylipins in pediatric sepsis and organ injury is uncertain. Recently, pediatric sepsis phenotypes were described, with phenotype D characterized by the highest proportion of acute kidney injury (AKI), multiple organ failure, and...
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