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Article

Deleterious variants in LTBP4 are associated with severe pediatric sepsis.

Pediatric research - 1 Jun 2026

Qin Yidi, Kernan Kate F, Bai Yulong, Shaffer John R, Urban Zsolt, Canna Scott, Pollack Murray M, Meert Kathleen, Newth Christopher, Shanley Tom, Harrison Rick E, Hall Mark, Carcillo Joseph A, Park Hyun-Jung

Abstract excerpt

BACKGROUND: Sepsis is a leading global health burden in children, and its unavoidable heterogeneity has hindered providing therapies beyond antibiotics and supportive care. Recently, we identified four computable phenotypes showing distinct cytokine profiles, clinical outcomes, and therapeutic response characteristics (PedSep-A, B, C, and D) in a multicenter pediatric sepsis cohort. METHODS: In the cohort data,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41076474
DOI: 10.1038/s41390-025-04420-3
PMCID: PMC13182162

Genes

LTBP4
CCDC157
PLA2G4E
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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