Article
Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1.
Critical care (London, England) - 26 Jun 2023
Atreya Mihir R, Cvijanovich Natalie Z, Fitzgerald Julie C, Weiss Scott L, Bigham Michael T, Jain Parag N, Schwarz Adam J, Lutfi Riad, Nowak Jeffrey, Allen Geoffrey L, Thomas Neal J, Grunwell Jocelyn R, Baines Torrey, Quasney Michael, Haileselassie Bereketeab, Alder Matthew N, Lahni Patrick, Ripberger Scarlett, Ekunwe Adesuwa, Campbell Kyle R, Walley Keith R, Standage Stephen W
Abstract excerpt
BACKGROUND: Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) mediated endotoxin clearance, holds promise as a potential therapeutic approach among adults. In contrast, we have previously demonstrated higher mortality in the juvenile host. Given the...
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