Article

<i>Streptococcus pyogenes</i> nuclease A interferes with host complement functions

2025-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Bacterial pathogens deploy diverse virulence factors to subvert host immunity, yet the molecular details of these interactions often remain unresolved. Here, we investigate the structure and host interactome of the Streptococcus pyogenes nuclease A (SpnA). We characterized the structure and dynamics of SpnA using hydrogen-deuterium exchange mass spectrometry and single-particle electron cryo mi...

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Literature Corpus work: 0de0c54f-ffde-5c42-984f-534aa55c609d
DOI: 10.1101/2025.08.25.672074

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