Article

A high-resolution cryo-EM structure of a bacterial M-protein reveals a compact structure that diverges from related M-proteins

2023-09-18

Abstract excerpt

The surface of Streptococcus pyogenes (GAS) is studded with virulence determinants, with the most abundant being the characteristic M-protein used to serotype various strains of the bacterium. There are >250 strains of GAS serotypically distinguished by their M-proteins. Major pathogenic mechanisms of GAS require that this microorganism hijacks host components for survival, many of which are involved in hemostasi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c692c4bf-11b4-5b2b-bf10-0f0cfe987bbd
DOI: 10.1101/2023.09.18.558297

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A high-resolution cryo-EM structure of a bacterial M-protein reveals a compact structure that diverges from related M-proteinsDOI 10.1101/2023.09.18.558297Read

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37Semantic proximity Read

Structural Study of MPN387, an Essential Protein for Gliding Motility of a Human-Pathogenic Bacterium, Mycoplasma pneumoniaeSemantic proximity Read

MPL36, a major plasminogen (PLG) receptor in pathogenic Leptospira, has an essential role during infectionSemantic proximity Read

Streptococcus pyogenes Forms Serotype- and Local Environment-Dependent Interspecies Protein ComplexesSemantic proximity Read

Streptococcus pyogenes nuclease A interferes with host complement functionsSemantic proximity Read

Coiled-Coil Irregularities and Instabilities in Group A Streptococcus M1 Are Required for VirulenceSemantic proximity Read

Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilmSemantic proximity Read

Coiled-coil irregularities of the M1 protein structure promote M1–fibrinogen interaction and influence group A Streptococcus host cell interactions and virulenceSemantic proximity Read

Reviewing advancement in Mycoplasma pneumoniae P30 adhesin protein provides insights for future diagnosis and treatmentSemantic proximity Read

The Crystal Structure of the Streptococcal Collagen-like Protein 2 Globular Domain from Invasive M3-type Group A Streptococcus Shows Significant Similarity to Immunomodulatory HIV Protein gp41Semantic proximity Read

Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune EvasionSemantic proximity Read

Coiled-coil destabilizing residues in the group A Streptococcus M1 protein are required for functional interaction.Semantic proximity Read