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Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

18 Feb 2009

Abstract excerpt

The human pathogen Neisseria meningitidis, a leading cause of bacterial meningitis and septic shock, possesses a surface protein, factor H binding protein or fHbp, that binds to host complement regulator factor H, thereby interfering with the immune response. Now the structure of the complex between human complement regulator factor H and fHbp has been determined. It reveals that the bacterial protein binds...

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PMID: 19225461
DOI: 10.1038/nature07769

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