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Molecular basis for <i>B. pertussis</i> interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complex

2020-10-07

Abstract excerpt

Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, C1-inhibitor (C1-INH) is a key regulator (inhibitor) of serine proteases of all the above-mentioned pathways. Recently, an autotransporter protein, Virulence Associated Gene 8 (Vag8) produced by the whopping cough causing pathogen, Bordetella pertussis...

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Literature Corpus work
007d760e-7bed-54ba-8f14-ad40ae2c887e
DOI
10.1101/2020.10.05.327577
Open publication

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Molecular basis for <i>B. pertussis</i> interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complexDOI 10.1101/2020.10.05.327577
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