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Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines

20 Mar 2023

Abstract excerpt

Neisseria meningitidis is a human-adapted pathogen that causes meningitis and sepsis worldwide. N. meningitidis factor H-binding protein (fHbp) provides a mechanism for immune evasion by binding human complement factor H (CFH) to protect it from complement-mediated killing. Here, we discuss features of fHbp which enable it to engage human CFH (hCFH), and the regulation of fHbp expression. Studies of host...

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Identifiers

PMID: 36941192
DOI: 10.1016/j.tim.2023.02.011

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