Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.

Journal of visualized experiments : JoVE - 27 Jun 2020

Showpnil Iftekhar A, Miller Kyle R, Taslim Cenny, Pishas Kathleen I, Lessnick Stephen L, Theisen Emily R

Abstract excerpt

Many cancers are characterized by chromosomal translocations which result in the expression of oncogenic fusion transcription factors. Typically, these proteins contain an intrinsically disordered domain (IDD) fused with the DNA-binding domain (DBD) of another protein and orchestrate widespread transcriptional changes to promote malignancy. These fusions are often the sole recurring genomic aberration in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogene Proteins, Fusion

Share to Protein Domains

Share to Proto-Oncogene Protein c-fli-1

Share to RNA-Binding Protein EWS

Share to Sarcoma, Ewing

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 32658189
DOI: 10.3791/61564
PMCID: PMC7484955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis.PMID 32658189Read ↗

The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcomaSemantic proximity Read ↗

SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing SarcomaSemantic proximity Read ↗

Ewing Sarcoma Protein: A Key Player in Human CancerSemantic proximity Read ↗

Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic OpportunitiesSemantic proximity Read ↗

A Molecular Function Map of Ewing's SarcomaSemantic proximity Read ↗

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1Semantic proximity Read ↗

Oncofusion-driven <i>de novo</i> enhancer assembly promotes malignancy in Ewing sarcoma <i>via</i> aberrant expression of the stereociliary protein LOXHD1Semantic proximity Read ↗

Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulationSemantic proximity Read ↗

Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic LandscapesSemantic proximity Read ↗

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational ModificationsSemantic proximity Read ↗

cIAP1 inhibitor of apoptosis is a tumor suppressor in Ewing sarcomaSemantic proximity Read ↗

Dynamic modelling of EWS::FLI1 fluctuations reveals molecular determinants of phenotypic tumor plasticity and prognosis in Ewing sarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.