Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins

Abstract excerpt

<h4>ABSTRACT</h4> Genes encoding the RNA-binding proteins F US, E WSR1, and T AF15 (FET proteins) are involved in chromosomal translocations in rare sarcomas. FET-rearranged sarcomas are often aggressive malignancies affecting patients of all ages. New therapies are needed. These translocations fuse the 5’ portion of the FET gene with a 3’ partner gene encoding a transcription factor (TF). The resulting fusion...

Topics

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• Cancer Mechanisms and Therapy
• Cancer-related gene regulation
• Chromatin Remodeling and Cancer
• Histone Deacetylase Inhibitors Research
• interferon and immune responses
• Protein Degradation and Inhibitors
• Sarcoma Diagnosis and Treatment
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

4ed45ff3-e98e-5273-86bf-79360972fc18

DOI

10.1101/2024.05.19.594897