Article

Scalable Human Cellular Models of Parkinson’s Disease Reveal A Druggable Link Between the Angiotensin Receptor 1 and α-Synuclein Pathology

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Parkinson’s disease (PD) involves progressive loss of midbrain dopaminergic (mDA) neurons in the substantia nigra. No disease-modifying treatments exist, only symptomatic relief. Our lab reported an unbiased screen in larval zebrafish identifying renin-angiotensin-aldosterone system (RAAS) inhibitors, including clinically used AGTR1 inhibitors for hypertension, as potent neu...

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Literature Corpus work: 0dca0763-28ed-5393-ab90-64e3a87a8cb6
DOI: 10.1101/2025.11.18.689137

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