Promoter sequence and architecture determine expression variability and confer robustness to genetic variants

Abstract excerpt

Genetic and environmental exposures cause variability in gene expression. Although most genes are affected in a population, their effect sizes vary greatly, indicating the existence of regulatory mechanisms that could amplify or attenuate expression variability. Here, we investigate the relationship between the sequence and transcription start site architectures of promoters and their expression variability across...

Topics

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• Base Sequence
• Binding Sites
• Gene Expression
• Genomics
• Mutation
• Promoter Regions, Genetic
• Transcription Factors
• Transcription, Genetic

Identifiers and source

Literature Corpus work

6da1a318-7bf3-5074-9dcd-0db9645389c1

DOI

10.1101/2021.10.29.466407