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Article

A compendium of genetic variations associated with promoter usage across 49 human tissues.

Nature communications - 9 Oct 2024

Yuan Jiapei, Tong Yang, Wang Le, Yang Xiaoxiao, Liu Xiaochuan, Shu Meng, Li Zekun, Jin Wen, Guan Chenchen, Wang Yuting, Zhang Qiang, Yang Yang

Abstract excerpt

Promoters play a crucial role in regulating gene transcription. However, our understanding of how genetic variants influence alternative promoter selection is still incomplete. In this study, we implement a framework to identify genetic variants that affect the relative usage of alternative promoters, known as promoter usage quantitative trait loci (puQTLs). By constructing an atlas of human puQTLs across 49...

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Identifiers

PMID: 39384785
DOI: 10.1038/s41467-024-53131-6
PMCID: PMC11464533

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