Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.

doi:10.1016/j.cell.2021.01.002

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Article

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition.

Cell - 4 Feb 2021

Litchfield Kevin, Reading James L, Puttick Clare, Thakkar Krupa, Abbosh Chris, Bentham Robert, Watkins Thomas B K, Rosenthal Rachel, Biswas Dhruva, Rowan Andrew, Lim Emilia, Al Bakir Maise, Turati Virginia, Guerra-Assunção José Afonso, Conde Lucia, Furness Andrew J S, Saini Sunil Kumar, Hadrup Sine R, Herrero Javier, Lee Se-Hoon, Van Loo Peter, Enver Tariq, Larkin James, Hellmann Matthew D, Turajlic Samra, Quezada Sergio A, McGranahan Nicholas, Swanton Charles

Abstract excerpt

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization. Here, we collated whole-exome and transcriptomic data for >1,000 CPI-treated patients across seven tumor types, utilizing standardized bioinformatics workflows and clinical outcome criteria to validate...

Topics

Biomarkers, Tumor
CD8 Antigens
Chemokine CXCL13
Chromosomes, Human, Pair 9
Cohort Studies
Cyclin D1
DNA Copy Number Variations
Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Amplification

Humans

Immune Checkpoint Inhibitors

Immune Evasion

Multivariate Analysis

Mutation

Neoplasms

Polymorphism, Single Nucleotide

Receptors, CCR5

T-Lymphocytes

Source

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Identifiers

PMID: 33508232
DOI: 10.1016/j.cell.2021.01.002
PMCID: PMC7933824

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