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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

19 Feb 2025

Abstract excerpt

A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA–lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ductal adenocarcinoma (PDAC), a lethal cancer with few mutations. At an extended 3.2-year median follow-up from a phase 1 trial of surgery, atezolizumab (PD-L1...

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PMID: 39972124
DOI: 10.1038/s41586-024-08508-4

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