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Estimating the relative contribution of transmission to bedaquiline resistance burden in tuberculosis. A transmission threshold model

2026-01-13

Abstract excerpt

Bedaquiline (BDQ) is a cornerstone antibiotic for treating multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB). Resistance to BDQ (BDQR) can arise through three mechanisms: spontaneous mutation, acquisition during treatment, or transmission of a resistant strain. We developed a transmission threshold model to estimate the contribution of each mechanism to BDQR burden in MDR/RR-TB We integrated four data so...

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Literature Corpus work
d059869d-1900-566d-98c9-1f20c4a4d70a
DOI
10.64898/2026.01.11.26343862
Open publication

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Estimating the relative contribution of transmission to bedaquiline resistance burden in tuberculosis. A transmission threshold modelDOI 10.64898/2026.01.11.26343862
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