Article

Understanding corticosterone fluctuations and HPA-axis regulation in a mouse model of Spinocerebellar ataxia type 3

2026-01-24

Abstract excerpt

Spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph Disease (MJD) is a neurodegenerative disease caused by a CAG triplet expansion in the ATXN3 gene, primarily characterized by motor impairments. However, SCA3/MJD also includes mood-related comorbidities that affect both patients and their caregivers. Current treatments focus on symptom management and supportive care, as no disease-modifying therapies are avai...

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Literature Corpus work: 0d6006c5-3972-5a04-9bd2-831399fb02f2
DOI: 10.64898/2026.01.22.701070

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Understanding corticosterone fluctuations and HPA-axis regulation in a mouse model of Spinocerebellar ataxia type 3DOI 10.64898/2026.01.22.701070Read

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