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Article

Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.

Psychoneuroendocrinology - 1 Jan 2014

Sawyer Nikki T, Papale Ligia A, Eliason Jessica, Neigh Gretchen N, Escayg Andrew

Abstract excerpt

Stress is known to trigger seizures in patients with epilepsy, highlighting the physiological stress response as a possible therapeutic target for epilepsy treatment. Nevertheless, little is currently known about how a genetic predisposition to epilepsy interacts with the stress response to influence seizure outcome. To address this question, we examined the effect of acute stress on seizure outcome in mice with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24138934
DOI: 10.1016/j.psyneuen.2013.09.018
PMCID: PMC3989103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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