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Article

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress.

Neurobiology of aging - 1 Apr 2012

Rothman Sarah M, Herdener Nathan, Camandola Simonetta, Texel Sarah J, Mughal Mohamed R, Cong Wei-Na, Martin Bronwen, Mattson Mark P

Abstract excerpt

Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but most studies of the effects of stress in models of AD utilize acute adverse stressors of questionable clinical relevance. The goal of this work was to determine how chronic psychosocial stress affects behavioral and pathological outcomes in an animal model of AD, and to elucidate underlying mechanisms. A triple-transgenic mouse model...

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Identifiers

PMID: 21855175
DOI: 10.1016/j.neurobiolaging.2011.07.005
PMCID: PMC4074356

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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