Article
The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety.
BMC genomics - 31 Oct 2012
Gonik Mariya, Frank Elisabeth, Keßler Melanie S, Czamara Darina, Bunck Mirjam, Yen Yi-Chun, Pütz Benno, Holsboer Florian, Bettecken Thomas, Landgraf Rainer, Müller-Myhsok Bertram, Touma Chadi, Czibere Ludwig
Abstract excerpt
BACKGROUND: The hypothalamic-pituitary-adrenal (HPA) axis is essential to control physiological stress responses in mammals. Its dysfunction is related to several mental disorders, including anxiety and depression. The aim of this study was to identify genetic loci underlying the endocrine regulation of the HPA axis. METHOD: High (HAB) and low (LAB) anxiety-related behaviour mice were established by selective...
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