Article
Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene.
Translational psychiatry - 16 Mar 2022
Caradonna Salvatore G, Einhorn Nathan R, Saudagar Vikram, Khalil Huzefa, Petty Gordon H, Lihagen Axel, LeFloch Claire, Lee Francis S, Akil Huda, Guidotti Alessandro, McEwen Bruce S, Gatta Eleonora, Marrocco Jordan
Abstract excerpt
The genomic effects of circulating glucocorticoids are particularly relevant in cortico-limbic structures, which express a high concentration of steroid hormone receptors. To date, no studies have investigated genomic differences in hippocampal subregions, namely the dorsal (dHPC) and ventral (vHPC) hippocampus, in preclinical models treated with exogenous glucocorticoids. Chronic oral corticosterone (CORT) in...
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