Article

Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma

2022-08-17

Abstract excerpt

<h4>Summary</h4> Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. Here, we utilize RNA-seq and metabolomics to identify candidate molecular effectors activated by these genetic drivers. We find glutathione biosynthesis, amino acid metabolism, mitochondrial unfolded protein response, and lipid peroxide s...

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Literature Corpus work: 6850b635-f7b1-53bf-8793-2a2b5f254e43
DOI: 10.1101/2022.08.16.504041

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