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Epigenetic Factors in Late-Onset Alzheimer&rsquo;s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

2018-12-24

Abstract excerpt

DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer&rsquo;s disease (LOAD).&nbsp; Methylenetetrahydrofolate reductase (MTHFR) gene mutations occur in most elderly patients with memory loss.&nbsp; MTHFR is critical for production of S-adenosyl-L-methionine (SAM), the principal methyl donor.&nbsp; A common mutation (1364T/T) of the cystathionine-&gamma;-lyase (CTH)...

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Literature Corpus work
0d3ed71e-e5fa-5bf5-85be-77c126a5fadb
DOI
10.20944/preprints201812.0267.v1
Open publication

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Epigenetic Factors in Late-Onset Alzheimer&rsquo;s Disease: <em>MTHFR</em> and<em> CTH </em>Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B VitaminsDOI 10.20944/preprints201812.0267.v1
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