Article
DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease.
Current Alzheimer research - 1 Jun 2012
Coppedè Fabio, Zitarosa Maria Teresa, Migheli Francesca, Lo Gerfo Annalisa, Bagnoli Silvia, Dardano Angela, Nacmias Benedetta, Mancuso Michelangelo, Monzani Fabio, Siciliano Gabriele, Sorbi Sandro, Migliore Lucia
Abstract excerpt
The vast majority of Alzheimer's disease (AD) are late-onset forms (LOAD) likely due to the contribution of genetic, environmental, and stochastic factors, superimposed on a physiologically age-related decline of neuronal functions. Increasing evidence indicates epigenetic modifications in LOAD brains, and many of the environmental factors associated with AD risk, such as heavy metals and dietary factors, are...
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