Article
Genetic effect of MTHFR C677T, A1298C, and A1793G polymorphisms on the age at onset, plasma homocysteine, and white matter lesions in Alzheimer's disease in the Chinese population.
Aging - 4 Apr 2021
Jiang Yaling, Xiao Xuewen, Wen Yafei, Wan Meidan, Zhou Lu, Liu Xixi, Wang Xin, Guo Lina, Liu Hui, Zhou Yafang, Wang Junling, Liao Xinxin, Shen Lu, Jiao Bin
Abstract excerpt
BACKGROUND: Three polymorphisms in the Methylenetetrahydrofolate reductase (MTHFR) gene (C677T, A1298C, and A1793G) were reported associated with AD. However, their genotype distributions and associations with age at onset (AAO), homocysteine, and white matter lesions (WML) were unclear in the Chinese AD population. METHOD: We determined the presence of C677T, A1298C, and A1793G polymorphisms in the MTHFR gene...
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