Article
Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls.
Antioxidants & redox signaling - 15 Jul 2012
Coppedè Fabio, Tannorella Pierpaola, Pezzini Ilaria, Migheli Francesca, Ricci Giulia, Caldarazzo lenco Elena, Piaceri Irene, Polini Antonio, Nacmias Benedetta, Monzani Fabio, Sorbi Sandro, Siciliano Gabriele, Migliore Lucia
Abstract excerpt
AIMS: We screened 378 late-onset Alzheimer's disease (LOAD) patients and 308 matched controls for the presence of the common MTHFR 677C>T, MTRR 66A>G, MTR 2756 A>G, and TYMS 28 bp repeat polymorphisms, searching for association with disease risk and age at onset. Moreover, we searched for correlation between each of the studied polymorphisms and available data on plasma homocysteine (Hcy), serum folate, and...
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