Article
Drivers underpinning the malignant transformation of giant cell tumour of bone.
The Journal of pathology - 1 Dec 2020
Fittall Matthew W, Lyskjaer Iben, Ellery Peter, Lombard Patrick, Ijaz Jannat, Strobl Anna-Christina, Oukrif Dahmane, Tarabichi Maxime, Sill Martin, Koelsche Christian, Mechtersheimer Gunhild, Demeulemeester Jonas, Tirabosco Roberto, Amary Fernanda, Campbell Peter J, Pfister Stefan M, Jones David Tw, Pillay Nischalan, Van Loo Peter, Behjati Sam, Flanagan Adrienne M
Abstract excerpt
The rare benign giant cell tumour of bone (GCTB) is defined by an almost unique mutation in the H3.3 family of histone genes H3-3A or H3-3B; however, the same mutation is occasionally found in primary malignant bone tumours which share many features with the benign variant. Moreover, lung metastases can occur despite the absence of malignant histological features in either the primary or metastatic lesions....
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