Article
H3F3A-mutated giant cell tumour of bone without giant cells-clinical presentation, radiology and histology of three cases.
Histopathology - 1 Nov 2021
Leinauer Benedikt, Wolf Eduard, Werner Mathias, Baumhoer Daniel, Breining Thomas, Luebke Andreas M, Maas Rainer, Schultheiß Markus, von Baer Alexandra, Sufi-Siavach Anusch, Moritz Christian, Geißler Sven, Mellert Kevin, Möller Peter, Barth Thomas F E, Jundt Gernot
Abstract excerpt
AIMS: Giant cell tumour of bone (GCTB) is histologically defined as a lesion containing reactive giant cells and a neoplastic mononuclear cell population; in up to 92% of cases, GCTB is characterised by a specific mutation of the histone gene H3F3A. The cellular composition ranges from giant-cell-rich to giant-cell-poor. The diagnosis of GCTB can be challenging, and several other lesions need to be excluded, e.g....
Topics
- Adult
- Bone Neoplasms
- Bone and Bones
- Chondroblastoma
- Diagnosis, Differential
- Female
- Giant Cell Tumor of Bone
- Giant Cells
- Histones
- Humans