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Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimics

14 Jan 2015

Abstract excerpt

Driver mutations in the two histone 3.3 (H3.3) genes, H3F3A and H3F3B, were recently identified by whole genome sequencing in 95% of chondroblastoma (CB) and by targeted gene sequencing in 92% of giant cell tumour of bone (GCT). Given the high prevalence of these driver mutations, it may be possible to utilise these alterations as diagnostic adjuncts in clinical practice. Here, we explored the spectrum of H3.3...

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PMID: 27499898
DOI: 10.1002/cjp2.13

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