Article

Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency

2023-02-04

Abstract excerpt

Cardiomyopathy is often fatal in Friedreich Ataxia (FA). However, the FA heart maintains adequate function until disease end stage, suggesting that it can initially adapt to the loss of frataxin (FXN). Conditional knockout mouse models with no Fxn expression show transcriptional and metabolic profiles of cardiomyopathy and mitochondrial integrated stress response (ISR mt ). However, ISR mt has not been investig...

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Literature Corpus work: d968d6d5-da3d-5fa3-977a-b43a3a014b4d
DOI: 10.1101/2023.02.03.526305

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