Article

A MYC Family Switch: L-MYC Drives and Maintains Neuroendocrine Lineage Programs in Prostate Cancer

2025-12-26

Abstract excerpt

<h4>ABSTRACT</h4> Neuroendocrine prostate cancer (NEPC) is an aggressive, therapy-resistant subtype that emerges through lineage plasticity following androgen receptor (AR) pathway inhibition. Although MYC family oncogenes are central to prostate cancer progression, the role of MYCL (L-MYC) in NEPC has remained unclear. Here, we show that MYCL is selectively and robustly upregulated in NEPC patient samples and ce...

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Literature Corpus work: 0d157738-3efb-59a2-85e6-c5828c89512a
DOI: 10.64898/2025.12.25.696507

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