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Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

12 Sept 2024

Abstract excerpt

Most patients with prostate adenocarcinoma develop resistance to therapies targeting the androgen receptor (AR). Consequently, a portion of these patients develop AR-independent neuroendocrine (NE) prostate cancer (NEPC), a rapidly progressing cancer with limited therapies and poor survival outcomes. Current research to understand the progression to NEPC suggests a model of lineage plasticity whereby AR-dependent...

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PMID: 39264686
DOI: 10.1158/0008-5472.can-24-1388

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