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Article

Cofilin loss in <i>Drosophila</i> contributes to myopathy through defective sarcomerogenesis and aggregate formation during muscle growth

2019-10-31

Abstract excerpt

<h4>SUMMARY</h4> Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila Cofilin ( DmCFL) , an actin depolymerizing factor, leads to the progressive disruption of sarcomere structure and muscle function in vivo . Loss...

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Literature Corpus work
da2b5114-2a7f-566a-9289-bf6b28f27bb3
DOI
10.1101/825448
Open publication

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Cofilin loss in <i>Drosophila</i> contributes to myopathy through defective sarcomerogenesis and aggregate formation during muscle growthDOI 10.1101/825448
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