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Article

Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality.

The Journal of cell biology - 8 Dec 2003

Fritz-Six Kimberly L, Cox Patrick R, Fischer Robert S, Xu Bisong, Gregorio Carol C, Zoghbi Huda Y, Fowler Velia M

Abstract excerpt

Tropomodulin1 (Tmod1) caps thin filament pointed ends in striated muscle, where it controls filament lengths by regulating actin dynamics. Here, we investigated myofibril assembly and heart development in a Tmod1 knockout mouse. In the absence of Tmod1, embryonic development appeared normal up to embryonic day (E) 8.5. By E9.5, heart defects were evident, including aborted development of the myocardium and...

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Identifiers

PMID: 14657235
DOI: 10.1083/jcb.200308164
PMCID: PMC2173615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality.PMID 14657235Read ↗

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