Article
A p21-GFP zebrafish model of senescence for rapid testing of senolytics <i>in vivo</i>
2022-09-19
Abstract excerpt
Senescence drives the onset and severity of multiple ageing-associated diseases as well as frailty. As a result, there has been an increased interest in mechanistic studies and in the search for compounds targeting senescent cells, known as senolytics. Mammalian models are commonly used to test senolytics and generate functional and toxicity data at the level of organs and systems, yet this is expensive and time c...
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Identifiers and source
- Literature Corpus work
- 0d059bde-e939-525a-940b-33792f01f2f2
- DOI
- 10.1101/2022.09.19.506911