Article
A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo
11 Apr 2023
Abstract excerpt
Abstract Senescence drives the onset and severity of multiple ageing‐associated diseases and frailty. As a result, there has been an increased interest in mechanistic studies and in the search for compounds targeting senescent cells, known as senolytics. Mammalian models are commonly used to test senolytics and generate functional and toxicity data at the level of organs and systems, yet this is expensive and...
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