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A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo

13 Jun 2023

Abstract excerpt

Senescent cells (SnCs) are implicated in aging and various age-related pathologies. Targeting SnCs can treat age-related diseases and extend health span. However, precisely tracking and visualizing of SnCs is still challenging, especially in in vivo environments. Here, we developed a near-infrared (NIR) fluorescent probe (XZ1208) that targets β-galactosidase (β-Gal), a well-accepted biomarker for cellular...

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PMID: 37312431
DOI: 10.1111/acel.13896

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