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Article

KATP channel mutation disrupts hippocampal network activity and nocturnal gamma shifts.

Brain : a journal of neurology - 3 Dec 2024

Burkart Marie-Elisabeth, Kurzke Josephine, Jacobi Robert, Vera Jorge, Ashcroft Frances M, Eilers Jens, Lippmann Kristina

Abstract excerpt

ATP-sensitive potassium (KATP) channels couple cell metabolism to cellular electrical activity. Humans affected by severe activating mutations in KATP channels suffer from developmental delay, epilepsy and neonatal diabetes (DEND syndrome). While the aetiology of diabetes in DEND syndrome is well understood, the pathophysiology of the neurological symptoms remains unclear. We hypothesized that impaired activity...

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PMID: 38748482
DOI: 10.1093/brain/awae157

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