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Article

Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome.

Genetics - 1 Aug 2020

Dyment David A, Schock Sarah C, Deloughery Kristen, Tran Minh Hieu, Ure Kerstin, Nutter Lauryl M J, Creighton Amie, Yuan Julie, Banderali Umberto, Comas Tanya, Baumann Ewa, Jezierski Anna, Boycott Kym M, Mackenzie Alex E, Martina Marzia

Abstract excerpt

Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated into neurons. Sodium currents of these neurons were compared with healthy control induced neurons. A novel...

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CA1 Region, Hippocampal
Electrophysiology
Epilepsies, Myoclonic
Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Potentials

NAV1.1 Voltage-Gated Sodium Channel

Pyramidal Cells

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Identifiers

PMID: 32554600
DOI: 10.1534/genetics.120.303399
PMCID: PMC7404236

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